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Key Publications (since 2008)

Kaur H, Takefuji M, Ngai CY, Carvalho J, Bayer J, Wietelmann A, Poetsch A, Hoelper S, Conway SJ, Möllmann H, Looso M, Troidl C, Offermanns S, Wettschureck N. Targeted Ablation of Periostin-Expressing Activated Fibroblasts Prevents Adverse Cardiac Remodeling in Mice. Circ. Res. 2016; 118: 1906–17

Sassmann-Schweda A, Singh P, Tang C, Wietelmann A, Wettschureck N, Offermanns S. Increased apoptosis and browning of TAK1-deficient adipocytes protects agains obesity. JCI Insight. 2016; 1: e81175

Strilic B, Yang L, Albarrán-Juárez J, Wachsmuth L, Han K, Müller UC, Pasparakis M, Offermanns S. Tumor cell-induced endothelial necroptosis via death receptor 6 promotes metastasis. Nature. 2016, 536: 215-218

Wang, SP, Chennupati R, Iring A, Kaur H, Wettschureck N, Offermanns S. Endothelial Piezo1 controls blood pressure by mediating flow-induced ATP-release. J. Clin. Invest. 2016; 126: 4527-4536

Offermanns S, Schwaninger M. Nutritional or pharmacological activation of HCA2 ameliorates neuroinflammation. Trends Mol. Med. 2015; 21: 245-255

Tang C, Ahmed K, Gille A, Lu S, Gröne HJ, Tunaru S, Offermanns S. Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes. Nat. Med. 2015; 21: 173-177

Wang S, Iring A, Strilic B, Albarrán Juárez J, Kaur H, Troidl K, Tonack S, Burbiel JC, Müller CE, Fleming I, Lundberg JO, Wettschureck N, Offermanns S. P2Y2 and Gq/G11 control blood pressure by mediating endothelial mechanotransduction. J. Clin. Invest. 2015; 125: 3077-3086

Xia J, Swiercz JM, Bañón-Rodríguez I, Sun T, Frederico G, Matkovic I, Franz T, Brakebusch CH, Kumanogoh A, Friedel RH, Martín-Belmonte F, Gröne HJ, Offermanns S, Worzfeld T. Semaphorin-plexin signaling controls mitotic spindle orientation during epithelial morphogenesis and repair. De.v Cell. 2015; 33: 299-313

Chen H, Assmann JC, Krenz A, Rahman M, Grimm M, Karsten CM, Köhl J, Offermanns S, Wettschureck N*, Schwaninger M*. Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarate's protective effect in EAE. J. Clin. Invest. 2014; 124: 2188-2192 * contributed equally

Offermanns S. Free Fatty Acid (FFA) and Hydroxy Carboxylic Acid (HCA) Receptors. Annu. Rev. Pharmacol. Toxicol. 2014; 54: 407-434

Worzfeld T, Offermanns S. Semaphorins and plexins as therapeutic targets. Nat. Rev. Drug Discov. 2014; 13: 603-621

Worzfeld T, Swiercz JM, Sentürk A, Genz B, Korostylev A, Deng S, Xia J, Hoshino M, Epstein JA, Chan AM, Vollmar B, Acker-Palmer A, Kuner R, Offermanns S. Genetic dissection of plexin signaling in vivo. Proc. Natl. Acad. Sci. USA. 2014; 111: 2194-2199

Schumacher D, Strilic B, Sivaraj KK, Wettschureck N, Offermanns S. Platelet-derived nucleoides promote tumor-cell transendothelial migration and metastasis via P2Y2 receptor. Cancer Cell. 2013; 24: 130-137

Sivaraj KK, Takefuji M, Schmidt I, Adams R, Offermanns S, Wettschureck N. G13 controls angiogenesis through regulation of VEGFR-2 expression. Dev. Cell. 2013; 25, 427-434

Takefuji M Krüger M, Sivaraj KK, Kaibuchi K, Offermanns S, Wettschureck N. RhoGEF12 controls cardiac remodeling by integrating G-protein- and integrin-dependent signaling cascades. J. Exp. Med. 2013; 210: 665-673

Althoff TF, Juarez JA, Troidl K, Tang C, Wang S, Wirth A, Takefuji M, Wettschureck N, Offermanns S. Procontractile G protein-mediated signaling pathways antagonistically regulate smooth muscle differentiation in vascular remodeling. J. Exp. Med. 2012; 209: 2277-2290

Blad CC, Tang C, Offermanns S (2012) G protein-coupled receptors for energy metabolites as new therapeutic targets. Nat. Rev. Drug Discov. 2012; 11: 603–619

Takefuji M, Wirth A, Lukasova M, Takefuji S, Boettger T, Braun T, Althoff T, Offermanns S, Wettschureck N. A G13-Mediated Signaling Pathway is Required for Pressure Overload-Induced Cardiac Remodeling and Heart Failure. Circulation. 2012; 126: 1972-1982

Tunaru S, Althoff TF, Nusing RM, Diener M, Offermanns S. Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP3 receptors. Proc. Natl. Acad. Sci. USA. 2012; 109: 9179-9184

Worzfeld T, Swiercz JM, Looso M, Straub BK, Sivaraj KK, Offermanns S. ErbB-2 signals through Plexin-B1 to promote breast cancer metastasis. J. Clin. Invest. 2012; 122: 1296-1305

Lukasova M, Malaval C, Gille A, Kero J, OffermannsS. Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells. J. Clin. Invest. 2011a; 121: 1163-1173

Lukasova M, Hanson J, Tunaru S, Offermanns S. Nicotinic acid (niacin): new lipid-independent mechanisms of action and therapeutic potentials. Trends. Pharmaco.l Sci. 2011b; 32: 700-707

Offermanns S, Colletti SL, Lovenberg TW, Semple G, Wise A, IJzerman AP. International Union of Basic and Clinical Pharmacology. LXXXII: Nomenclature and Classification of Hydroxy-carboxylic Acid Receptors (GPR81, GPR109A, and GPR109B). Pharmacol. Rev. 2011; 63: 269-290

Ahmed K, Tunaru S, Tang C, Müller M, Gille A, Sassmann A, Hanson J, Offermanns S. An autocrine lactate loop mediates insulin-dependent inhibition of lipolysis through GPR81. Cell Metab. (2010); 11: 311-319

Hanson J, Gille A, Zwykiel S, Lukasova M, Clausen BE, Ahmed K, Tunaru S, Wirth A, Offermanns S. Keratinocytes express GPR109A and mediate epidermal effects of nicotinic acid and mono-Methyl fumarate via COX-2-dependent prostanoid formation J. Clin. Invest. 2010; 120: 2910-2919

Sassmann A, Gier B, Gröne HJ, Drews G, Offermanns S, Wettschureck N. The Gq/G11-mediated signaling pathway is critical for autocrine potentiation of insulin secretion J. Clin. Invest. (2010); 120: 2184-2193

Ahmed K, Tunaru S, Langhans CD, Hanson J, Michalski CW, Kölker S, Jones PM, Okun JG, Offermanns S. Deorphanization of GPR109B as a receptor for the beta-oxidation intermediate 3-OH-octanoic acid and its role in the regulation of lipolysis. J. Biol. Chem. (2009); 284: 21928-21933

Herroeder S, Reichardt P, Sassmann A, Zimmermann B, Jaeneke D, Hoeckner J, Hollmann MW, Fischer KD, Vogt S, Grosse R, Hogg N, Gunzer M, Offermanns S, Wettschureck N. Guanine nucleotide-binding proteins of the G12 family shape immune functions by controlling CD4+ T cell adhesiveness and motility. Immunity. (2009) 30: 708-720

Korhonen H, Fisslthaler B, Moers A, Wirth A, Habermehl D, Wieland T, Schütz G, Wettschureck N, Fleming I, Offermanns S. Anaphylactic shock depends on endothelial Gq/G11. J. Exp. Med. (2009); 206: 411-420

Gille A, Bodor ET, Ahmed K, Offermanns S. Nicotinic acid: Pharmacological effects and mechanisms of action. Annu. Rev. Pharmacol. Toxicol. (2008); 48: 79-106

Wirth A, Benyó Z, Lukasova M, Leutgeb B, Wettschureck N, Gorbey S, Őrsy P, Horváth B, Maser-Gluth C, Greiner E, Lemmer B, Schütz G, Gutkind S, Offermanns S. G12/G13-LARG-mediated signalling in vascular smooth muscle is required for salt-induced hypertension. Nat. Med. (2008) 14: 64-68

Worzfeld, T, Wettschureck, N, Offermanns S.G(12)/G(13)-mediated signalling in mammalian physiology and disease. Trends Pharmacol. Sci. (2008): 29: 582-589