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Prof. Dr. med. Nina Wettschureck
Phone: +49 (0)6032 705 1214
E-Mail:  This email address is being protected from spambots. You need JavaScript enabled to view it.
Address:   Max-Planck-Institute for Heart and Lung Research
Dept. of Pharmacology
Ludwigstraße 43
61231 Bad Nauheim
Germany

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Since 2012                    Professor for Molecular Pharmacology, University of Frankfurt / Main

Since 2009                    Group Leader, Max-Planck-Institute for Heart and Lung Research Bad Nauheim.

2007                             "Habilitation" for Pharmacology and Toxicology, University of Heidelberg

2000 - 2009                   Postdoctoral Research Fellow, Institute of Pharmacology, University of Heidelberg

1998 – 2000                  Postdoctoral Research Fellow, Institute of Pharmacology, FU Berlin

1996 – 1998                  Internship, Dept. of Internal Medicine V, University of Heidelberg

1990 – 1996                  Studies of Medicine, M.D. degree, University of Frankfurt / Main, Germany

 

RESEARCH INTERESTS:

G-Protein-mediated signaling in the vascular and immune system under physiological and pathophysiological conditions.

 

SELECTED PUBLICATIONS:

Chen H, Assmann JC, Krenz A, RahmanM, Grimm M, Karsten CM, Köhl J, Offermanns S, Wettschureck N*, Schwaninger M*: Hydroxy-carboxylic acid receptor 2 mediates dimethyl fumarate‘s protective effect in EAE. J Clin Invest 124(5):2188-92. (*contributed equally)

Schumacher D, Strilic B, Sivaraj KK, Wettschureck N, Offermanns S (2013) Platelet-derived nucleotides promote tumor-cell transendothelial migration and metastasis via P2Y2 receptor. Cancer Cell 24:130-7.

Sivaraj KK, Takefuji M, Schmidt I, Adams RH, Offermanns S, Wettschureck N (2013) G13 controls angiogenesis through regulation of VEGFR-2 expression. Dev Cell 25:427-34.

Sassmann A, Gier B, Gröne HJ, Drews G, Offermanns S, Wettschureck N: The Gq/G11-mediated signaling pathway is critical for autocrine potentiation of insulin secretion in mice. J Clin Invest 120: 2184-93, 2010. 

Herroeder S, Reichardt P, Sassmann A, Zimmermann B, Jaeneke D, Hoeckner J, Hollmann MW, Fischer KD, Vogt S, Grosse R, Hogg N, Gunzer M, Offermanns S, Wettschureck N: G-proteins of the G12/13 family shape immune functions by controlling CD4+ T-cell adhesive-ness and motility. Immunity 30:708-20, 2009.

Korhonen H, Fisslthaler B, Moers A, Wirth A, Habermehl D, Wieland T, Schütz G, Wettschureck N, Fleming I, Offermanns S: Anaphylactic shock depends on endothelial Gq/G11. J Exp Med 206:411-20, 2009.

Wettschureck N, Lee E, Libutti SK, Offermanns S, Robey PG, SpiegelAM: Parathyroid-specific double knockout of Gq- and G11-alpha subunits leads to a phenotype resembling germline knockout of the Ca++-sensing receptor. Mol Endocrinol 21:274-80, 2007.

 RiekenS, SassmannA, HerroederS, Wallenwein B, Moers A, Offermanns S, Wettschureck N: G12/G13 family G-proteins regulate marginal zone B cell maturation, migration and polari-zation, J Immunol 177:2985-93, 2006.

Wettschureck N, Van der Stelt M, Tsubokawa H, Krestel H, Moers A, Petrosino S, Schütz G, Di Marzo V, Offermanns S: Forebrain-specific inactivation of Gq/G11 family G-proteins results in age-dependent epilepsy and impaired endocannabinoid formation. Mol Cell Biol 26:5888-94, 2006.

Wettschureck N, Offermanns S: Mammalian G proteins and their cell type specific functions. Physiol Rev. 2005 Oct;85(4):1159-204, 2005.

Wettschureck N, Rütten H, Zywietz A, Gehring D, Wilkie T, Chen J, Chien KR, Offermanns S: Cardiomyocyte restricted Galphaq/Galpha11-deficiency prevents pressure overload induced myocardial hypertrophy. Nat Med 7:1236-40, 2001.